Cosmomycin D. A new anthracycline antibiotic.
نویسندگان
چکیده
منابع مشابه
DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains.
Cosmomycin D (CosD) is the major constituent fraction isolated from a culture of Streptomyces olindensis ICB20. The ability of this compound to intercalate with double-stranded DNA was studied by gel mobility shift assays and electrospray ionization mass spectrometry (ESI-MS). ESI-MS experiments showed that the complex of CosD with 16-mer double-stranded DNA was at least as stable as a complex ...
متن کاملGenome Sequence of Streptomyces olindensis DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D
Streptomyces olindensis DAUFPE 5622, which was isolated from a Brazilian soil sample, produces the antitumor anthracycline cosmomycin D. The genome sequence is 9.4 Mb in length, with a G+C content of 71%. Thirty-four putative secondary metabolite biosynthetic gene clusters were identified, including the cosmomycin D cluster.
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Sir: During the course of our screening for inducers of mouse myeloid leukemic cell (M1)1) differentiation, we have recently isolated four active components related to the carminomycins from the cultured broth of an actinomycete. The isolation and structures of these components are reported in this paper. The producing organism of the active substances was isolated from a soil sample collected ...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1985
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.49.259